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GLP-1 Savers
Cheapest GLP-1

Programs to compare

Alternatives to Lyfe Rx

Lyfe Rx scores a 66 on our Value Score. These are the GLP-1 programs worth pricing instead — every one scored on the same six factors, with the teaser-rate traps flagged so you pay the real price.

Read our Lyfe Rx review →CoreAge Rx vs Lyfe Rx →
Featured partner

CoreAge Rx

Grade B · Good Value

Advertised price

From $79/mo

From $79/mo (compounded semaglutide; confirm total at checkout)

Pricing to watch. CoreAge Rx advertises compounded semaglutide from $79 and tirzepatide from $129 per month, with dose-flat pricing stated in its FAQ. Confirm the total and refund terms before paying.
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EdgeRx

Grade B+ · Good Value

Advertised price

$229/mo

Save ~34% vs brand self-pay
No teaser step-up. A men's-only protocol shop with flat, disclosed GLP-1 pricing, a named Chief Medical Advisor, and a named 503A compounding pharmacy — rare transparency for this tier of the ranking.
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Invigor Medical

Grade B- · Fair Price

Advertised price

From $225

From $225 (GLP-1 plan; the page states no billing period)

Pricing to watch. A long-running injectables clinic that moved to a new website and now quotes GLP-1s from $225 and tirzepatide from $350 a month, with the doctor consult and supplies counted inside both figures.
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FMmeds

Grade B- · Fair Price

Advertised price

From $225/mo

From $225/mo (all doses, compounded)

No teaser step-up. FMmeds is a Manhattan Beach-based DTC telehealth platform selling compounded semaglutide and tirzepatide co-formulated with vitamin B12, with no membership fee and a free initial visit billed only on approval.
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Enhance MD

Grade B+ · Good Value

Advertised price

$249 every 4 weeks

$249 every 4 weeks (13 charges a year)

Pricing to watch. A transparent, dose-flat compounded menu (microdose to sema+tirz combo) with 6-month lab testing and NAD+ on the side — priced higher at entry, with a first-month sema teaser to read past.
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Medsol RX

Grade B- · Fair Price

Advertised price

From $209/mo

From $209/mo (compounded)

Pricing to watch. Medsol RX is a GLP-1 weight-loss telehealth program offering compounded semaglutide (from $209/mo) and tirzepatide, prescribed by board-certified clinicians via OpenLoop and shipped nationwide.
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Renlo Health

Grade B · Good Value

Advertised price

$199

$199 (semaglutide), billed monthly

Save ~43% vs brand self-pay
No teaser step-up. One of the few programs here whose headline is the actual monthly rate, with the prescribing physician and the dispensing pharmacy both named.
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ARSYNL Rx

Grade C · Watch List

Advertised price

$219/mo month-to-month

$219/mo month-to-month (compounded semaglutide)

Save ~37% vs brand self-pay
Pricing to watch. ARSYNL Rx sells compounded semaglutide at $219 a month and tirzepatide at $269, as a weekly injection or a needle-free HypoSpray, from a veteran-founded telehealth practice.
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Onyx Weight Loss

Grade C · Watch List

Advertised price

From $228/mo

From $228/mo (starting dose, compounded)

Pricing to watch. Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states.
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Compare them head-to-head

Value Scores are our editorial judgment per the methodology. "% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026).We earn a commission when you start treatment through some links on this site, at no extra cost to you. CoreAge Rx is a featured partner, and providers we work with may appear first. It never changes a Value Score. Prices change — confirm on each provider's site. Not medical advice; see our disclosure.

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