Direct Meds review
One of the few programs offering a sublingual GLP-1 alongside the injection, with the medication, nurse support and shipping bundled into a single monthly figure rather than billed beside it.
Est. first month
From $249/mo
$249/mo sublingual
FDA warning letter. The FDA issued directmeds.com, Inc. dba DirectMeds a warning letter in September 2025. Check it on the FDA database.
How much does Direct Meds cost?
The price Direct Meds publishes is $249/mo sublingual. Compounded semaglutide is listed at $249/mo sublingual · $297/mo injectable. Tirzepatide is listed at $299/mo sublingual · $399/mo injectable. We flag this one to watch: confirm the ongoing rate with Direct Meds before you count on it, because a low first month can step up afterward. That works out about 87% under our ~$1,349/mo brand-name cash reference.
- Semaglutide
- $249/mo sublingual · $297/mo injectable
- Tirzepatide
- $299/mo sublingual · $399/mo injectable
- Coverage
- Not publicly listed
- Brand-name
- Compounded only
The Value Score card
Direct Meds scored on our six published factors. See the methodology.
Why it's a deal
- Rare oral/sublingual route offered alongside injectable on both molecules
- All-inclusive pricing with no separate membership fee
- Both semaglutide and tirzepatide available, sublingual or injectable
Read the fine print
- The FDA issued this operator a warning letter in September 2025 — it is on the public FDA warning-letter database
- Compounded only (launched 2024) — not FDA-approved
- Bulk 6- and 12-month plans and new-customer discounts are advertised but not priced on the page, so the ongoing rate is the one to budget against
- Newer, ambiguous operator running multiple domains — do your own diligence
- States served are not publicly listed
The bottom line
Best for: Needle-averse shoppers who want a sublingual option on both molecules and will do their own diligence on a newer, ambiguous operator. One of the few programs offering a sublingual GLP-1 alongside the injection, with the medication, nurse support and shipping bundled into a single monthly figure rather than billed beside it.
Ranked #44 of 418 programs we track — see our #1 deal, CoreAge Rx, for comparison.
Compare with other deals
The programs scoring closest to Direct Meds, out of 417 others we track.
Shopping Direct Meds against a specific rival? We put it head to head with our top-scoring pick on CoreAge Rx vs Direct Meds, and every program that undercuts or outscores it — starting with Precision Telemed, the closest match on score — is ranked on the Direct Meds alternatives ranking.
- From $139.99/moPrecision Telemed— A multi-vertical telehealth storefront where the GLP-1s are priced from $139.99, and where the cheapest number on the front page belongs to a peptide rather than to either weight-loss drug.80/100
- From about $80/mo (clinic range $80-$135)Potere Health MD— A physician-led clinic in St. George, Utah offering GLP-1 care in person or by telehealth, quoting an approximate $80 to $135 a month rather than a fixed price per drug.80/100
- $109 every 28 days, all-inPepti— Compounded semaglutide at $109 and tirzepatide at $179 with the consultation and shipping inside the figure — billed every twenty-eight days, which is thirteen charges a year, on a site whose own cost pages still print two older prices.80/100
- $81/mo (compounded)BiltRx— BiltRx sells compounded semaglutide at $81 and tirzepatide at $129 a month beside brand-name Mounjaro and Wegovy, labeling each product FDA approved or not on the storefront itself.79/100
- From $189/mo (starting dose, compounded)Bionomy Health— Bionomy Health is a physician-led, direct-to-consumer men's telehealth brand offering compounded GLP-1 weight-loss medication alongside testosterone, peptides, and longevity protocols.79/100
- $139/moBlis MD— Blis MD is a US telehealth offering personalized GLP-1 weight-loss treatment with compounded semaglutide and tirzepatide, prescribed after a free virtual consultation with a licensed provider.79/100
More programs we track (24)
- #48 EverSlim81
- #49 GOAL.MD81
- #50 Good Girl Rx81
- #51 Rivo Health81
- #52 Trillium Meds81
- #53 Eden81
- #57 Ivologist80
- #58 KERNX Health80
- #59 Queen RX80
- #60 Revel RX80
- #61 Semaglutide Online80
- #62 Zera Health80
- #69 Bliv79
- #70 Harper Meds79
- #71 HealthSource79
- #72 Maves79
- #73 Ozari Health79
- #74 Rylo Health79
- #75 Trava Health79
- #76 TRYM Health79
- #77 Zappy Health79
- #78 Zeuss79
- #79 Vaylen79
- #80 AgelessRx79
387 more are reviewed too — see every GLP-1 program we track, ranked.
Pricing and coverage on this page were read from Direct Meds's own website on ; the Value Score is our editorial judgment per the methodology. “% vs brand-name” compares the lowest disclosed monthly price against a ~$1,349/mo brand-name cash reference. Prices change — confirm on Direct Meds's site. Not medical advice; see our disclosure.