Direct Meds review
Value Score79/100
Direct Meds sells compounded semaglutide and tirzepatide as under-the-tongue drops or weekly injections, from $249 a month, with the doctor review, supplies and shipping in that price.
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Advertised price
From $249/mo
$249/mo sublingual
FDA warning letter. The FDA issued directmeds.com, Inc. dba DirectMeds a warning letter in September 2025. Check it on the FDA database.
How much does Direct Meds cost?
The price Direct Meds publishes is $249/mo sublingual. Compounded semaglutide is listed at $249/mo sublingual · $297/mo injectable. Tirzepatide is listed at $299/mo sublingual · $399/mo injectable. We flag this one to watch: confirm the ongoing rate with Direct Meds before you count on it. That works out about 29% under the $349/mo brand-name self-pay price for Wegovy.
- Semaglutide
- $249/mo sublingual · $297/mo injectable
- Tirzepatide
- $299/mo sublingual · $399/mo injectable
- Coverage
- All states except Louisiana and Mississippi
- Brand-name
- Compounded only
The Value Score card
Direct Meds scored on our six published factors. See the methodology.
Direct Meds · 79/100
From $249/mo
What's good
- Both molecules in two forms at Direct Meds: daily sublingual drops ($249 semaglutide, $299 tirzepatide) or a weekly injection ($297 and $399).
- Direct Meds says the monthly price includes the medication, supplies, the doctor review, nurse support and shipping, with no membership fee on top.
- Direct Meds names its two dispensing pharmacies and which states each one fills: CraftedRx in Missouri for most states, ChemistryRx in Pennsylvania for six others.
- Coverage is spelled out: Direct Meds serves every state except Louisiana and Mississippi, where it says telehealth weight-loss prescribing is not allowed.
- If the provider does not approve your prescription, Direct Meds says you get a full refund of the first month you paid at checkout.
- Direct Meds says a provider reviews your chart within 24 hours, often under five, and approved orders placed before 2 pm Central ship the same day by UPS in a cold pack.
- HSA and FSA cards are accepted at Direct Meds, and it will supply receipts for reimbursement.
- Direct Meds shows a LegitScript certification on its site and gives you nurse access through the patient portal, plus email and phone support during business hours.
- Refills are requested in the Direct Meds portal, where the prescriber reviews your dose and writes the next prescription; the injection schedule steps up every four weeks.
Read the fine print
- The FDA sent Direct Meds a warning letter in September 2025. It is on the FDA's public warning-letter list.
- Direct Meds' answers say 'no subscriptions', but its terms describe auto-refill billed every 30 days. Turn auto-refill off in the portal at least 48 hours before the next charge to stop it.
- Once Direct Meds ships, medication cannot be refunded, and a prescription order generally cannot be canceled more than 24 hours after you place it.
- Direct Meds takes payment for the first month before a provider reviews your intake. The refund applies only if you are not approved.
- The default Direct Meds plan ships a 90-day supply at once and bills monthly, so ask what you owe if you stop partway through those three months.
- Direct Meds advertises new-customer discounts and 6- and 12-month bulk pricing but prints no figures for them, so budget from the monthly price.
- Direct Meds is compounded only and not FDA-approved: no brand-name Wegovy, Ozempic or Zepbound.
- At $297 for injectable semaglutide and $399 for tirzepatide, the Direct Meds injection is well above the cheaper injection programs on this site; its sublingual drops are the reason to pick it.
The bottom line
Best for: Needle-averse shoppers who want a sublingual option on either molecule and are comfortable with a seller that carries an FDA warning letter.
For comparison, see CoreAge Rx, a featured partner (Value Score 81/100).
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Compare with other deals
The programs scoring closest to Direct Meds, out of 428 others we track.
Shopping Direct Meds against a specific rival? We put it head to head with our featured partner on CoreAge Rx vs Direct Meds, and every program that undercuts or outscores it — starting with Care Clinics, the closest match on score — is ranked on the Direct Meds alternatives ranking.
- $259 per 7-week courseCare Clinics— Prices a course rather than a month - $299 buys twelve weeks of semaglutide on a fixed titration schedule, which is cheap, but it is not a subscription and there is no monthly rate to compare.80/100
- $109 every 28 days, all-inPepti— Compounded semaglutide at $109 and tirzepatide at $179 with the consultation and shipping inside the figure — billed every twenty-eight days, which is thirteen charges a year, on a site whose own cost pages still print two older prices.80/100
- $99 every 4 weeksLttl— Lttl prices compounded semaglutide at $99 and tirzepatide at $149 per 4-week supply, the same at every dose, with cheaper rates if you prepay 12, 24 or 52 weeks.79/100
- $81/moBiltRx— BiltRx sells compounded semaglutide at $81 and tirzepatide at $129 a month beside brand-name Mounjaro and Wegovy, labeling each product FDA approved or not on the storefront itself.79/100
- From $189/moBionomy Health— Bionomy Health is a physician-led, direct-to-consumer men's telehealth brand offering compounded GLP-1 weight-loss medication alongside testosterone, peptides, and longevity protocols.79/100
- $139/moBlis MD— Blis MD is a US telehealth offering personalized GLP-1 weight-loss treatment with compounded semaglutide and tirzepatide, prescribed after a free virtual consultation with a licensed provider.79/100
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395 more are reviewed too — see every GLP-1 program we track, ranked.
Pricing and coverage on this page come from Direct Meds' own website; the Value Score is our editorial judgment per the methodology."% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026). Prices change — confirm on Direct Meds' site. Not medical advice; see our disclosure.