Head-to-head · Value Score
HealthRX vs RxSpan MD
Two GLP-1 deals, scored on the same six factors. HealthRX lands a Value Score of 84, RxSpan MD a 86. Here's what each one really costs past month one — and where each one bites back.
HealthRX
Grade B+ · Good Value
Advertised price
$165/mo month-to-month
$165/mo month-to-month ($149 first month)
RxSpan MD
Grade A- · Great Deal
Advertised price
$249/mo month-to-month
$249/mo month-to-month (as low as $175/mo on the 12-month plan)
The verdict
RxSpan MD takes it on Value Score, 86 to 84 — an est. $249/mo month-to-month (as low as $175/mo on the 12-month plan) first month, though we flag its pricing to watch. HealthRX isn't out of it: Shoppers who want a LegitScript-certified compounded program in any state and are willing to prepay a few months to bring the monthly cost down.
Deal-by-deal
The numbers that decide it. Green ✓ marks the stronger side on each line.
| Deal | HealthRX | RxSpan MD |
|---|---|---|
| Value Score | 84 (B+) | 86 (A-) |
| Advertised price | $165/mo month-to-month ($149 first month) | $249/mo month-to-month (as low as $175/mo on the 12-month plan) |
| Save vs brand self-pay | — | — |
| Semaglutide | $165/mo month-to-month on Subscribe & Save after a $149 first month ($190 for a single month) · $125/mo on a 3-month plan ($374 every 3 months) · $97/mo on a 12-month plan ($1,163 up front) | $249/mo month-to-month (as low as $175/mo on the 12-month plan) |
| Tirzepatide | $214/mo month-to-month on Subscribe & Save after a $193 first month ($239 for a single month) · $201/mo on a 3-month plan ($602 every 3 months) · $177/mo on a 12-month plan ($2,123 up front) | $329/mo month-to-month (as low as $243/mo) |
| Both molecules | Yes | Yes |
| Pricing | Watch | Watch |
| Coverage | All 50 states | All 50 states |
Factor by factor
The six factors behind each Value Score. The orange bar marks the stronger side. See the methodology.
HealthRX
A LegitScript-certified program selling compounded semaglutide and tirzepatide as weekly injections, $165 or $214 a month on a rolling subscription and less on 3- and 12-month plans.
What's good
- LegitScript-certified (#50087439), a third-party check you can look up
- HealthRX publishes every plan price in one table, including what each plan renews at, before you start an intake
- The plan price includes the medication, the provider review and free overnight shipping, and HealthRX serves all 50 states
- Cancel by email; HealthRX says it refunds any dose that has not shipped
The fine print
- Compounded medication is not FDA-approved, and HealthRX sells no brand-name or oral option
- The HealthRX entry rates are plan prices: $97 and $177 need twelve months paid up front, so month to month costs $165 and $214 after a lower first month
- HealthRX's subscriptions renew automatically until you email to cancel, so set a reminder before each renewal
RxSpan MD
A broad, physician-led menu - compounded and oral GLP-1 plus an advertised brand-name lane under a named plastic surgeon - priced at $249 a month for semaglutide, with the advertised low rates attached to a plan.
What's good
- Available in all 50 states
- Transparent, all-inclusive published pricing — consult, medication, supplies, shipping and support in one price; cancel or change plans anytime, with the card advertising as low as $175/mo on compounded semaglutide for anyone who commits to a plan
- Both injectable and a real oral (capsule) route, on compounded sema/tirz plus an advertised brand-name lane
- Physician-led by a named, board-certified founder (Dr. John Diaz, plastic surgeon); 24/7 unlimited messaging and coaching, free shipping
The fine print
- Compounded semaglutide and tirzepatide are not FDA-approved and are not the same as Wegovy, Ozempic or Zepbound
- RxSpan MD's brand-name lane is expensive: $1,069 for a first month of Zepbound, $1,299 for Ozempic and $1,349 for Wegovy
- RxSpan MD's $175 and $243 rates need a 12-month plan paid up front with a promo code, and that plan auto-renews
- Prescription isn't guaranteed at RxSpan MD — a provider reviews eligibility after checkout
We earn a commission when you start treatment through some links on this site, at no extra cost to you. It never changes a Value Score.
Neither one the right fit? Every program that outscores HealthRX is ranked on the HealthRX alternatives ranking, and the same list for the other side is on alternatives to RxSpan MD.
More head-to-heads
The programs scoring closest to this pair, side by side.
Prices, states and verification reflect each program's public disclosures at last check; the Value Score is our editorial judgment per the methodology. "% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026). Prices change — confirm on each provider's site. Not medical advice; see our disclosure.