Head-to-head · Value Score
NewSelf vs Trimi Health
Two GLP-1 deals, scored on the same six factors. NewSelf lands a Value Score of 87, Trimi Health a 84. Here's what each one really costs past month one — and where each one bites back.
NewSelf
Grade A- · Great Deal
Advertised price
$134.99/mo at every dose
$134.99/mo at every dose (as low as $99.97 on a longer plan)
Save ~61% vs brand self-pay
Trimi Health
Grade B+ · Good Value
Advertised price
$175/mo month-to-month
$175/mo month-to-month ($99/mo on the annual plan, $1,188 upfront)
The verdict
NewSelf takes it on Value Score, 87 to 84 — an est. $134.99/mo at every dose (as low as $99.97 on a longer plan) first month, with no teaser step-up baked in. Trimi Health isn't out of it: Shoppers ready to prepay three, six or twelve months for a lower rate, who want the pharmacy and clinician network named before they start.
Deal-by-deal
The numbers that decide it. Green ✓ marks the stronger side on each line.
| Deal | NewSelf | Trimi Health |
|---|---|---|
| Value Score | 87 (A-) | 84 (B+) |
| Advertised price | $134.99/mo at every dose (as low as $99.97 on a longer plan) | $175/mo month-to-month ($99/mo on the annual plan, $1,188 upfront) |
| Save vs brand self-pay | ~61% | — |
| Semaglutide | $134.99/mo at every dose (as low as $99.97 on a longer plan) | $175/mo month-to-month · $145/mo on the quarterly plan ($435 every 3 months) · $120/mo on 6 months ($720 upfront) · $99/mo on the annual plan ($1,188 upfront) |
| Tirzepatide | $224.99/mo at every dose (as low as $144.49 on a longer plan) | $235/mo month-to-month · $199/mo on the quarterly plan ($597 every 3 months) · $175/mo on 6 months ($1,050 upfront) · $125/mo on the annual plan ($1,500 upfront) |
| Both molecules | Yes | Yes |
| Pricing | Flat — no step-up | Watch |
| Coverage | 49 states | All 50 states |
Factor by factor
The six factors behind each Value Score. The orange bar marks the stronger side. See the methodology.
NewSelf
NewSelf sells compounded semaglutide with B12 or glycine at $134.99 a month and compounded tirzepatide with B6 and glycine at $224.99, both held flat across every dose, in 49 states.
Why it's a deal
- The rate holds at every dose on both molecules — semaglutide across 0.25 mg to 2.5 mg, tirzepatide across 2.5 mg to 15 mg — so titrating up costs nothing extra
- Both products are compounded with B12, B6 or glycine rather than sold as bare molecules, and the formulation is stated on the product card
- HSA and FSA eligible, with the health screening, shipping and ongoing support inside the price
- Names the 49 states it covers rather than implying nationwide reach
The fine print
- The prominent $99.97 and $144.49 figures are plan floors, not the standing rates — those are $134.99 and $224.99
- Not available in Mississippi or Louisiana
- A "Tirzepatide Plus" tier at $399 a month sits above the standard product, so the flat-rate promise applies within a tier rather than across the range
- Compounded only — no FDA-approved brand-name route
Trimi Health
Trimi Health charges $175 a month for compounded semaglutide and $235 for tirzepatide month to month, down to $99 and $125 if you pay for a year up front, at the same price for every dose.
What's good
- Trimi prints all four billing terms side by side: month to month, quarterly, six months and a year, with the full charge next to each monthly figure.
- Paid up front for a year, Trimi works out to $99 a month for semaglutide and $125 for tirzepatide, and the annual plan does not renew on its own.
- The price is the same at every dose, so moving up the dose schedule does not raise your Trimi bill.
- Trimi names its dispensing pharmacies, BelieveRx (with its Texas pharmacy license number) and GreenwichRx, and its clinician network, Arora Health.
- Trimi's plan price includes the medication if prescribed, provider consultations, portal messaging with the care team and free overnight shipping once compounded.
- The Trimi intake takes about 5 to 10 minutes online, and Trimi says signup to delivery usually takes two to four days.
- Trimi says the Arora Health network it uses operates in all 50 states, and it publishes a conditional six-month money-back policy.
- Trimi's FAQ is plain about limits: a prescription is not assured, delivery times are estimates, and brand-drug trial results do not predict results with its compounded medicine.
- Trimi ships vials and tells you to confirm the dose with the pharmacist, since milligrams and syringe units measure different things. That matters if you have never drawn from a vial.
- Trimi patients message providers and the care team in the portal, and its contact page lists phone and email support as well.
The fine print
- Trimi's headline $99 and $125 are annual-plan figures billed $1,188 or $1,500 at once; month to month it is $175 for semaglutide and $235 for tirzepatide.
- Turning off renewal at Trimi does not cancel or refund a prepaid term, so you are committed for the full three, six or twelve months you buy.
- Trimi's quarterly and monthly plans renew automatically until you contact the care team and get a confirmation.
- Trimi is cash pay only. It does not bill insurance, and HSA or FSA eligibility is up to your plan administrator.
- On a long Trimi plan the medication does not necessarily ship all at once, so ask the care team how deliveries are spaced.
- Trimi sells compounded injections only: no FDA-approved brand-name drug and no oral route, and compounded medication is not FDA-approved.
- Trimi is a newer brand without LegitScript certification, so check the pharmacy licenses yourself before buying on price.
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Neither one the right fit? Every program that outscores NewSelf is ranked on the NewSelf alternatives ranking, and the same list for the other side is on alternatives to Trimi Health.
More head-to-heads
The programs scoring closest to this pair, side by side.
Prices, states and verification reflect each program's public disclosures at last check; the Value Score is our editorial judgment per the methodology. "% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026). Prices change — confirm on each provider's site. Not medical advice; see our disclosure.