Head-to-head · Value Score
RxSpan MD vs NewSelf
Two GLP-1 deals, scored on the same six factors. RxSpan MD lands a Value Score of 86, NewSelf a 87. Here's what each one really costs past month one — and where each one bites back.
RxSpan MD
Grade A- · Great Deal
Advertised price
$249/mo month-to-month
$249/mo month-to-month (as low as $175/mo on the 12-month plan)
NewSelf
Grade A- · Great Deal
Advertised price
$134.99/mo at every dose
$134.99/mo at every dose (as low as $99.97 on a longer plan)
Save ~61% vs brand self-payThe verdict
NewSelf takes it on Value Score, 87 to 86 — an est. $134.99/mo at every dose (as low as $99.97 on a longer plan) first month, with no teaser step-up baked in. RxSpan MD isn't out of it: People who want a wide, doctor-fronted menu with all-inclusive pricing and nationwide coverage, and who will budget against the month-to-month figure rather than the advertised one.
Deal-by-deal
The numbers that decide it. Green ✓ marks the stronger side on each line.
| Deal | RxSpan MD | NewSelf |
|---|---|---|
| Value Score | 86 (A-) | 87 (A-) |
| Advertised price | $249/mo month-to-month (as low as $175/mo on the 12-month plan) | $134.99/mo at every dose (as low as $99.97 on a longer plan) |
| Save vs brand self-pay | — | ~61% |
| Semaglutide | $249/mo month-to-month (as low as $175/mo on the 12-month plan) | $134.99/mo at every dose (as low as $99.97 on a longer plan) |
| Tirzepatide | $329/mo month-to-month (as low as $243/mo) | $224.99/mo at every dose (as low as $144.49 on a longer plan) |
| Both molecules | Yes | Yes |
| Pricing | Watch | Flat — no step-up |
| Coverage | All 50 states | 49 states |
Factor by factor
The six factors behind each Value Score. The orange bar marks the stronger side. See the methodology.
RxSpan MD
A broad, physician-led menu - compounded and oral GLP-1 plus an advertised brand-name lane under a named plastic surgeon - priced at $249 a month for semaglutide, with the advertised low rates attached to a plan.
What's good
- Available in all 50 states
- Transparent, all-inclusive published pricing — consult, medication, supplies, shipping and support in one price; cancel or change plans anytime, with the card advertising as low as $175/mo on compounded semaglutide for anyone who commits to a plan
- Both injectable and a real oral (capsule) route, on compounded sema/tirz plus an advertised brand-name lane
- Physician-led by a named, board-certified founder (Dr. John Diaz, plastic surgeon); 24/7 unlimited messaging and coaching, free shipping
The fine print
- Compounded semaglutide and tirzepatide are not FDA-approved and are not the same as Wegovy, Ozempic or Zepbound
- RxSpan MD's brand-name lane is expensive: $1,069 for a first month of Zepbound, $1,299 for Ozempic and $1,349 for Wegovy
- RxSpan MD's $175 and $243 rates need a 12-month plan paid up front with a promo code, and that plan auto-renews
- Prescription isn't guaranteed at RxSpan MD — a provider reviews eligibility after checkout
NewSelf
NewSelf sells compounded semaglutide with B12 or glycine at $134.99 a month and compounded tirzepatide with B6 and glycine at $224.99, both held flat across every dose, in 49 states.
Why it's a deal
- The rate holds at every dose on both molecules — semaglutide across 0.25 mg to 2.5 mg, tirzepatide across 2.5 mg to 15 mg — so titrating up costs nothing extra
- Both products are compounded with B12, B6 or glycine rather than sold as bare molecules, and the formulation is stated on the product card
- HSA and FSA eligible, with the health screening, shipping and ongoing support inside the price
- Names the 49 states it covers rather than implying nationwide reach
The fine print
- The prominent $99.97 and $144.49 figures are plan floors, not the standing rates — those are $134.99 and $224.99
- Not available in Mississippi or Louisiana
- A "Tirzepatide Plus" tier at $399 a month sits above the standard product, so the flat-rate promise applies within a tier rather than across the range
- Compounded only — no FDA-approved brand-name route
We earn a commission when you start treatment through some links on this site, at no extra cost to you. It never changes a Value Score.
Neither one the right fit? Every program that outscores RxSpan MD is ranked on the RxSpan MD alternatives ranking, and the same list for the other side is on alternatives to NewSelf.
More head-to-heads
The programs scoring closest to this pair, side by side.
Prices, states and verification reflect each program's public disclosures at last check; the Value Score is our editorial judgment per the methodology. "% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026). Prices change — confirm on each provider's site. Not medical advice; see our disclosure.