Head-to-head · Value Score
RxSpan MD vs Trimi Health
Two GLP-1 deals, scored on the same six factors. RxSpan MD lands a Value Score of 86, Trimi Health a 84. Here's what each one really costs past month one — and where each one bites back.
RxSpan MD
Grade A- · Great Deal
Advertised price
$249/mo month-to-month
$249/mo month-to-month (as low as $175/mo on the 12-month plan)
Trimi Health
Grade B+ · Good Value
Advertised price
$175/mo month-to-month
$175/mo month-to-month ($99/mo on the annual plan, $1,188 upfront)
The verdict
RxSpan MD takes it on Value Score, 86 to 84 — an est. $249/mo month-to-month (as low as $175/mo on the 12-month plan) first month, though we flag its pricing to watch. Trimi Health isn't out of it: Shoppers ready to prepay three, six or twelve months for a lower rate, who want the pharmacy and clinician network named before they start.
Deal-by-deal
The numbers that decide it. Green ✓ marks the stronger side on each line.
| Deal | RxSpan MD | Trimi Health |
|---|---|---|
| Value Score | 86 (A-) | 84 (B+) |
| Advertised price | $249/mo month-to-month (as low as $175/mo on the 12-month plan) | $175/mo month-to-month ($99/mo on the annual plan, $1,188 upfront) |
| Save vs brand self-pay | — | — |
| Semaglutide | $249/mo month-to-month (as low as $175/mo on the 12-month plan) | $175/mo month-to-month · $145/mo on the quarterly plan ($435 every 3 months) · $120/mo on 6 months ($720 upfront) · $99/mo on the annual plan ($1,188 upfront) |
| Tirzepatide | $329/mo month-to-month (as low as $243/mo) | $235/mo month-to-month · $199/mo on the quarterly plan ($597 every 3 months) · $175/mo on 6 months ($1,050 upfront) · $125/mo on the annual plan ($1,500 upfront) |
| Both molecules | Yes | Yes |
| Pricing | Watch | Watch |
| Coverage | All 50 states | All 50 states |
Factor by factor
The six factors behind each Value Score. The orange bar marks the stronger side. See the methodology.
RxSpan MD
A broad, physician-led menu - compounded and oral GLP-1 plus an advertised brand-name lane under a named plastic surgeon - priced at $249 a month for semaglutide, with the advertised low rates attached to a plan.
What's good
- Available in all 50 states
- Transparent, all-inclusive published pricing — consult, medication, supplies, shipping and support in one price; cancel or change plans anytime, with the card advertising as low as $175/mo on compounded semaglutide for anyone who commits to a plan
- Both injectable and a real oral (capsule) route, on compounded sema/tirz plus an advertised brand-name lane
- Physician-led by a named, board-certified founder (Dr. John Diaz, plastic surgeon); 24/7 unlimited messaging and coaching, free shipping
The fine print
- Compounded semaglutide and tirzepatide are not FDA-approved and are not the same as Wegovy, Ozempic or Zepbound
- RxSpan MD's brand-name lane is expensive: $1,069 for a first month of Zepbound, $1,299 for Ozempic and $1,349 for Wegovy
- RxSpan MD's $175 and $243 rates need a 12-month plan paid up front with a promo code, and that plan auto-renews
- Prescription isn't guaranteed at RxSpan MD — a provider reviews eligibility after checkout
Trimi Health
Trimi Health charges $175 a month for compounded semaglutide and $235 for tirzepatide month to month, down to $99 and $125 if you pay for a year up front, at the same price for every dose.
What's good
- Trimi prints all four billing terms side by side: month to month, quarterly, six months and a year, with the full charge next to each monthly figure.
- Paid up front for a year, Trimi works out to $99 a month for semaglutide and $125 for tirzepatide, and the annual plan does not renew on its own.
- The price is the same at every dose, so moving up the dose schedule does not raise your Trimi bill.
- Trimi names its dispensing pharmacies, BelieveRx (with its Texas pharmacy license number) and GreenwichRx, and its clinician network, Arora Health.
- Trimi's plan price includes the medication if prescribed, provider consultations, portal messaging with the care team and free overnight shipping once compounded.
- The Trimi intake takes about 5 to 10 minutes online, and Trimi says signup to delivery usually takes two to four days.
- Trimi says the Arora Health network it uses operates in all 50 states, and it publishes a conditional six-month money-back policy.
- Trimi's FAQ is plain about limits: a prescription is not assured, delivery times are estimates, and brand-drug trial results do not predict results with its compounded medicine.
- Trimi ships vials and tells you to confirm the dose with the pharmacist, since milligrams and syringe units measure different things. That matters if you have never drawn from a vial.
- Trimi patients message providers and the care team in the portal, and its contact page lists phone and email support as well.
The fine print
- Trimi's headline $99 and $125 are annual-plan figures billed $1,188 or $1,500 at once; month to month it is $175 for semaglutide and $235 for tirzepatide.
- Turning off renewal at Trimi does not cancel or refund a prepaid term, so you are committed for the full three, six or twelve months you buy.
- Trimi's quarterly and monthly plans renew automatically until you contact the care team and get a confirmation.
- Trimi is cash pay only. It does not bill insurance, and HSA or FSA eligibility is up to your plan administrator.
- On a long Trimi plan the medication does not necessarily ship all at once, so ask the care team how deliveries are spaced.
- Trimi sells compounded injections only: no FDA-approved brand-name drug and no oral route, and compounded medication is not FDA-approved.
- Trimi is a newer brand without LegitScript certification, so check the pharmacy licenses yourself before buying on price.
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Neither one the right fit? Every program that outscores RxSpan MD is ranked on the RxSpan MD alternatives ranking, and the same list for the other side is on alternatives to Trimi Health.
More head-to-heads
The programs scoring closest to this pair, side by side.
Prices, states and verification reflect each program's public disclosures at last check; the Value Score is our editorial judgment per the methodology. "% vs brand-name self-pay" compares a program's lowest disclosed monthly price against $349/mo, Wegovy's self-pay price at NovoCare Pharmacy, every standard dose after the two-month intro offer (checked October 2026). Prices change — confirm on each provider's site. Not medical advice; see our disclosure.